Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines.
نویسندگان
چکیده
Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched α-branched amines (up to 99 % ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.
منابع مشابه
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ورودعنوان ژورنال:
- Chemistry
دوره 22 23 شماره
صفحات -
تاریخ انتشار 2016